HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 4-iodobenzoate → HCID 9802822, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 4-iodobenzoate | HCID 142891 | — |
| Reactant | HCID 9795781 | HCID 9795781 | — |
| Catalyst | Benzyltrimethylammonium chloride | HCID 5963 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 9802822 | HCID 9802822 | — |
Reaction Steps
In the a) route of scheme 3, compound 5 is reacted with ethyl 4-iodo-benzoate in the presence of triethylamine (Et3N), trimethyl-benzylammonium chloride (Me3N (Bn) Cl) and tetrakistriphenylphosphine palladium (Pd(PPh3)4) to give ethyl 4-[4-[3-(3-oxo-2-azabicyclo[2.2.2]octan-2-yl)propoxy]phenylethynyl]-benzoate (compound 15), then 4-[4-[3-(3-oxo-2-azabicyclo[2.2.2]octan-2-yl)propoxy]phenylethynyl]-benzoic acid (compound 16 ) is provided by hydrolysis of compound 15.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06124460 |
| Source dataset | uspto-grants-2000_09 |
| ORD ID | ord-c466b451704640079e958b37f8a628fd |
| Source note | uspto-grants-2000_09 |