HCID 10878747, compound → (+)-Solketal

Participants

Reaction Conditions

Reaction Steps

10% Palladium-carbon (3 g) was added to thus obtained (S)-4-benzyloxymethyl-2,2-dimethyl-1,3-dioxolane (16.692 g, 74.88 mmol) in ethanol(250 ml) and the mixture was stirred for 3 hours at 25° C. under an atmosphere of hydrogen. After the reaction was over, palladium-carbon was filtered off and the solution was condensed in vacuo. The crude product was distilled to give 8.61 g of (S)-2,2-dimethyl-1,3-dioxolane-4-methanol (yield 87%, b.p. 65° C. at 3 mmHg, optical purity 97.8% e.e., specific rotation [α]D20 +10.92°(c=1,MeOH))).

Provenance & Evidence