反应详情

15.9 g of methyl chloroformate (165 mmol) are added at from 20 to 25° C. to a solution of 18.3 g of o-(N,N-dimethylaminomethyl)-phenylglyoxylic acid methyl ester Va (content 88.6%; 73.3 mol) in 100 ml of toluene. The reaction mixture is stirred at RT overnight, heated at 60° C. for 1 h, cooled and concentrated by evaporation in vacuo. 15.3 g (content 83%; yield 82%) of product are obtained.

1. temperatureheated at 60° C. for 1 h
2. temperaturecooled
3. concentrationconcentrated by evaporation in vacuo
4. custom15.3 g (content 83%; yield 82%) of product are obtained