Methyl chloroformate → Methyl 2-(chloromethyl)-phenylglyoxylate

HRID 1955365노트

반응식

HRID 1955365 반응식
[Cl:1]C(OC)=O.[CH3:6][O:7][C:8](=[O:21])[C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[CH2:17]N(C)C)=[O:10]>C1(C)C=CC=CC=1>[CH3:6][O:7][C:8](=[O:21])[C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[CH2:17][Cl:1])=[O:10]

참가 물질

4

반응물 2

HCID 6586Methyl chloroformateHCID 22446584o-(N,N-dimethylaminomethyl)-phenylglyoxylic acid methyl ester

생성물 1

HCID 14697243Methyl 2-(chloromethyl)-phenylglyoxylate수율 82%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

15.9 g of methyl chloroformate (165 mmol) are added at from 20 to 25° C. to a solution of 18.3 g of o-(N,N-dimethylaminomethyl)-phenylglyoxylic acid methyl ester Va (content 88.6%; 73.3 mol) in 100 ml of toluene. The reaction mixture is stirred at RT overnight, heated at 60° C. for 1 h, cooled and concentrated by evaporation in vacuo. 15.3 g (content 83%; yield 82%) of product are obtained.

후처리

  1. temperatureheated at 60° C. for 1 h
  2. temperaturecooled
  3. concentrationconcentrated by evaporation in vacuo
  4. custom15.3 g (content 83%; yield 82%) of product are obtained

출처 및 근거

ORD 기록
ord-5563ccd0bced4605baabab88a4550feb
출처 데이터셋
uspto-grants-2000_09
특허 번호
US06124493

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