Water → HCID 11113037, compound

Participants

Reaction Steps

Crude product 27 of Example 6 (6 g, 12.73 mmol) was dissolved in dioxane (15 mL) and water (15 mL) and cooled in an ice bath. 2N sodium hydroxide was added to this solution till pH of the solution reached 10. The heterogenous mixture was stirred at room temperature until it became homogenous. The homogenous layer was extracted with ether, and the aqueous layer acidified to pH 2 using 4N HCl. This was extracted with dichloromethane (150×3 mL), and dried over magnesium sulphate to give 5.52 g of 29 (95% yield from compound 26) as a pure white solid.

Provenance & Evidence