HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-Methoxyimino-1H-1,5-benzodiazepine-2,4(3H,5H)-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | O-Phenylenediamine | HCID 7243 | — |
| Reactant | Diethyl 2-(methoxyimino)malonate | HCID 533643 | — |
| Solvent | Sodium Methoxide | HCID 10942334 | — |
| Product | 3-Methoxyimino-1H-1,5-benzodiazepine-2,4(3H,5H)-dione | HCID 19070814 | — |
Reaction Steps
A mixture of iN sodium methylate (162 ml), o-phenylenediamine (17.5 g, 162 mmol) and diethyl 2-(methoxyimino)malonate (32.91 g, 162 mmol) is heated to reflux for 5 hr. After cooling, the mixture is acidified with 2N HCl (162 ml) and pale yellowish crystals (14.3 g, 41%) are filtered off.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05776929 |
| Source dataset | uspto-grants-1998_07 |
| ORD ID | ord-1fc1aabf11b34aa49ae3405463bbb15f |
| Source note | uspto-grants-1998_07 |