HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Methoxyimino-1H-1,5-benzodiazepine-2,4(3H,5H)-dione → 3-amino-1H-1,5-benzodiazepine-2,4(3H,5H)-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Methoxyimino-1H-1,5-benzodiazepine-2,4(3H,5H)-dione | HCID 19070814 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-amino-1H-1,5-benzodiazepine-2,4(3H,5H)-dione | HCID 21955806 | 62% |
Reaction Steps
A solution of 3-methoxyimino-1H-1,5-benzodiazepine-2,4(3H,5H)-dione (3.78 g, 17.4 mmol) and 10% Pd/C (1.8 g) in methanol (300 ml) is stirred for 15 hr under hydrogen gas. After removing the catalyst by filtration, the filtrate is concentrated under reduced pressure. The resultant residue is crystallized from methanol to obtain Compound 4 (2.062 g, 62%). M.p. =290°-291° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05776929 |
| Source dataset | uspto-grants-1998_07 |
| ORD ID | ord-3750335c39af421c8408009500338618 |
| Source note | uspto-grants-1998_07 |