Dimethylformamide → HCID 70101090, compound

Participants

Reaction Steps

A mixture of 3-amino-1H-1,5-benzodiazepine-2,4(3H,5H)-dione (1.91 g, 10.0 mmol) and 3-(3-(carbomethoxy)propylcarbamoyloxymethyl)phenylisocyanate (3.507 g, 12.0 mmol) in dimethylformamide (19 ml) is stirred for 1 hr at room temperature. To the residue obtained by concentrating the reaction mixture under reduced pressure is added methylene chloride (300 ml) and methanol (100 ml), and the mixture is stirred for 30 min at room temperature. The reaction mixture is filtered through a silica gel (50 g) layer to obtain Compound 6 (4.822 g, 100%) as colorless crude crystals. M.p. =151°-155° C.

Provenance & Evidence