Hydrochloric Acid → HCID 19070811, compound

Participants

Reaction Steps

To a solution of previously prepared 1,5-bis-(cyclopropylcarbonylmethyl)-3-(t-butoxycarbonylamino)-1H-1,5-benzodiazepine-2,4(3H,5H)-dione 14 h (3.188 g) in ethyl acetate (16 ml) is added a solution of 4N HCl in ethyl acetate (14 ml) under ice-cooling. After stirring the reaction mixture for 15 hr at room temperature, crystalline preparations are filtered off. The resultant crystals are dissolved into methylene chloride/methanol (5:1) and washed with saturated aqueous sodium hydrogencarbonate solution. The organic layer is dried over magnesium sulfate and concentrated under reduced pressure. Crystallization from a mixture of methylene chloride, methanol and diisopropyl ether yields the titled Compound 16 h (2.092 g; yield, 84%).

Provenance & Evidence