1-Piperazineacetic acid, methyl ester → 3-(1-BOC-4-piperidyl)-5-[4-(methoxycarbonylmethyl)piperazino]methyloxazolidin-2-one
Reaction equation
[N:1]1([CH2:7][C:8]([O:10][CH3:11])=[O:9])[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[C:12]([N:19]1[CH2:24][CH2:23][CH:22]([N:25]2[CH2:29][CH:28]([CH2:30]OS(C)(=O)=O)[O:27][C:26]2=[O:36])[CH2:21][CH2:20]1)([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13]>>[C:12]([N:19]1[CH2:20][CH2:21][CH:22]([N:25]2[CH2:29][CH:28]([CH2:30][N:4]3[CH2:5][CH2:6][N:1]([CH2:7][C:8]([O:10][CH3:11])=[O:9])[CH2:2][CH2:3]3)[O:27][C:26]2=[O:36])[CH2:23][CH2:24]1)([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13]Participants
3
Procedure
Analogously to Example 1, starting from methyl 2-piperazinoacetate [obtainable by reaction of methyl α-chloroacetate with piperazine] by reaction with 3-(1-BOC-4-piperidyl)-5-methanesulfonyloxymethyloxazolidin-2-one, 3-(1-BOC-4-piperidyl)-5-[4-(methoxycarbonylmethyl)piperazino]methyloxazolidin-2-one is obtained after customary working up.
Sources & evidence
- ORD record
- ord-0638e4bcca0549779e0a9fb27977e197
- Source dataset
- uspto-grants-1998_07
- Patent number
- US05776937
Reaction notes
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