HCID 11673521, compound → HCID 19071332, compound

Participants

Reaction Steps

1,3-Bis[2-(1-cyclohexen-1-yl)ethyl]urea (from step (a) example 8, 10.82 g, 39.14 mmol) was dissolved in methanol (400 mL)-water (12 mL) and shaken with 10% palladium on carbon (600 mg) under hydrogen (55 psi) on a Parr apparatus for 7.5 h. The catalyst was filtered off (Celite) and volatiles were removed in vacuo to leave 1,3-bis(2-cyclohexylethyl)urea as white crystals (10.72 g, 98%), m.p. 150°-151.5° C.; 1H-NMR (DMSO-d6) consistent with structure.

Provenance & Evidence