反应详情

2-Cyano-N-(cyclohexylmethyl)acetamide (from step (a) example 13, 7.66 g, 42.5 mmol) was also condensed with butyl isocyanate (Adrich, 7.60 ml, 63.7 mmol) in anhydrous toluene (70 mL) in a Parr bomb at 120° C. for 24 h to provide 1-butyl-3-(2-cyanoacetyl)-1-(cyclohexylmethyl)urea (3.51 g, 30%), 1H-NMR (DMSO-d6) consistent with structure. Unreacted 2-cyano-N-(cyclohexylmethyl)acetamide was also recovered (5.97 g, 70%).