HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 1-(4-Hydroxyphenyl)cyclopentane-1-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Product | 1-(4-Hydroxyphenyl)cyclopentane-1-carboxamide | HCID 18801096 | — |
Reaction Steps
1-Hydroxybenzotriazole (3.68 g, Aldrich), 1-Ethyl-3-(3-Dimethylaminopropyl)-carbodiimide hydrochloride (5.28 g Sigma) and N-Methylmorpholine (2.78 g, Aldrich) were added, under nitrogen, to a stirred solution of the product from Example 4(a) (5.0 g) in dry tetrahydrofuran (THF). The mixture was stirred at RT for four hours, then slowly added to liquid ammonia (excess) at -60° C. After one hour, the mixture was warmed to RT and stirred overnight.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05776951 |
| Source dataset | uspto-grants-1998_07 |
| ORD ID | ord-f2b4f400ca4d42d688c0ec9313a4326f |
| Source note | uspto-grants-1998_07 |