反应详情

A solution of the product produced in step B (1.25 g, 3.9 mmol), K2 CO3 (3.5 g, 25.3 mmol) and 60 ml MeOH/H2O 1:1 was refluxed for 3 h. The methanol was evaporated, and the aqueous residue acidified to pH 1 using 6N HCl. The aqueous phase was extracted with EtOAc. The organic phase was washed with water, dried (MgSO4), and evaporated to produce a crude glass which was recrystallized from EtOAc-hexane to afford 1.1 g of the title compound as a solid, m. p. 198°-201° C.

1. customThe methanol was evaporated
2. extractionThe aqueous phase was extracted with EtOAc
3. washThe organic phase was washed with water
4. dry with materialdried (MgSO4)
5. customevaporated
6. customto produce a crude glass which
7. customwas recrystallized from EtOAc-hexane