反应详情

To a stirred 60° C. dioxane (35 mL) solution of 1-[4-hydroxy-3-[(methylsulfonyl)amino]phenyl]ethanone (2.06 g, 8.7 mmol) was rapidly added Br2 (1.48 g, 9.2 mmol). After one hour, the solution was cooled, concentrated and diluted with H2O. After filtration, the product was washed thoroughly with H2O, then with i-PrOH (9 mL), and air-dried to obtain the title compound (2.43 g, 84%).

1. customTo a stirred 60° C.
2. temperaturethe solution was cooled
3. concentrationconcentrated
4. additiondiluted with H2O
5. filtrationAfter filtration
6. washthe product was washed thoroughly with H2O
7. dry with materialwith i-PrOH (9 mL), and air-dried