HuagongsheHuagongshe Chemistry Print Report · For research reference only
alpha-(3,4-Dimethoxyphenyl)benzeneethanamine → N-[3-[2-[[1-(3,4-Dimethoxyphenyl)-2-phenylethyl]amino]1-hydroxyethyl]phenyl]methanesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | alpha-(3,4-Dimethoxyphenyl)benzeneethanamine | HCID 411116 | — |
| Reactant | N-[3-(2-bromoacetyl)phenyl]methanesulfonamide | HCID 11346858 | — |
| Product | N-[3-[2-[[1-(3,4-Dimethoxyphenyl)-2-phenylethyl]amino]1-hydroxyethyl]phenyl]methanesulfonamide | HCID 19073125 | — |
Reaction Steps
The title compound was prepared by coupling α-(3,4-dimethoxyphenyl)benzeneethanamine, prepared as described in step C of Example 1, with 2-bromo-1-[3-[(methylsulfonyl)amino]phenyl]ethanone via the procedure described in step D of Example 1. The title compound, after silica gel chromatography, was purified by preparative HPLC using 49% solvent B to elute the desired material from a YMC S10 C18 column.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05776983 |
| Source dataset | uspto-grants-1998_07 |
| ORD ID | ord-a83721cb05a348c7adf3f8e5a081c474 |
| Source note | uspto-grants-1998_07 |