4,4'-Dimethoxybenzhydrylamine → HCID 19073199, compound

HRID 1955798Notes

Reaction equation

HRID 1955798 reaction equation
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([F:11])=[C:7]([NH:12][S:13]([CH3:16])(=[O:15])=[O:14])[CH:6]=1)=[O:4].[CH3:17][O:18][C:19]1[CH:34]=[CH:33][C:22]([CH:23]([NH2:32])[C:24]2[CH:29]=[CH:28][C:27]([O:30][CH3:31])=[CH:26][CH:25]=2)=[CH:21][CH:20]=1>>[CH3:31][O:30][C:27]1[CH:26]=[CH:25][C:24]([CH:23]([NH:32][CH2:2][CH:3]([C:5]2[CH:10]=[CH:9][C:8]([F:11])=[C:7]([NH:12][S:13]([CH3:16])(=[O:15])=[O:14])[CH:6]=2)[OH:4])[C:22]2[CH:33]=[CH:34][C:19]([O:18][CH3:17])=[CH:20][CH:21]=2)=[CH:29][CH:28]=1

Participants

3

Reactant 2

HCID 3500424,4'-DimethoxybenzhydrylamineHCID 18615210HCID 18615210, compound

Product 1

HCID 19073199HCID 19073199, compound

Procedure

The title compound was prepared by coupling of 2-bromo-1-[4-fluoro-3-[(methylsulfonyl)amino]phenyl]ethanone with 4,4'-dimethoxybenzhydrylamine (preparation described in Example 14) following the procedure described in step D of Example 1, except for the following modification: the crude product after coupling and reduction was chromatographed on silica gel using 75% EtOAc/hexane to elute pure title compound.

Workup

  1. customreduction was chromatographed on silica gel using 75% EtOAc/hexane
  2. washto elute pure title compound

Sources & evidence

ORD record
ord-ec6796d879bb42d1b03c1d7131277225
Source dataset
uspto-grants-1998_07
Patent number
US05776983

Reaction notes

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