Formamide → HCID 19073168, compound

Participants

Reaction Conditions

Reaction Steps

Following the procedure in step C of Example 1, 4,4'-dimethoxybenzophenone was converted to N-[bis-(4-methoxyphenyl)methyl]formamide. To a solution of the above formamide (2.2 g, 8.1 mmol) in anhydrous CH2Cl2 (50 ml) at 0° C. under N2 was added 1.0M solution of BBr3 in CH2Cl2 (20.0 ml). After warming to 20° C. and stirring for one hour, the reaction mixture was quenched with aq. NaHCO3 and extracted with EtOAc. The EtOAc fractions were washed with brine, dried over MgSO4 and then stripped to obtain 1.9 g of N-[bis-(4-hydroxyphenyl)methyl]formamide.

Provenance & Evidence