HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloroaniline → 2-(4-Methoxyphenyl)propionamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloroaniline | HCID 7812 | — |
| Reactant | (S)-alpha-[N-[(1,1-Dimethylethyl)carbonyl]amino]-4-methoxy-alpha-methylbenzeneacetic acid | HCID 69968462 | — |
| Product | 2-(4-Methoxyphenyl)propionamide | HCID 20269889 | — |
Reaction Steps
(S)-α-[N-[(1,1-Dimethylethyl)carbonyl]amino]-α-methyl-4-methoxybenzeneacetic acid (preparation described in step A of Example 101) was condensed with 4-chloroaniline following the procedure described in step A of Example 99. Pure (S)-N-(4-chlorophenyl)-α-[N-[(1,1-dimethylethyl)carbonyl]]-amino!-α-methyl-4-methoxybenzeneacetamide, obtained after chromatography on silica gel using 20% EtOAc/hexane as eluant, was converted to the title compound following the procedure described in step A of Example 98.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05776983 |
| Source dataset | uspto-grants-1998_07 |
| ORD ID | ord-1e7d0ad73a5c474d98bb913f70e5b77b |
| Source note | uspto-grants-1998_07 |