HCID 19072467, compound → 1-(4-Bromobutyl)-2-methoxybenzene

Participants

Reaction Steps

2-(4-bromobutyl)anisole 2-Bromoanisole (2.0 g, 1.07 mmol) in tetrahydrofuran (20 ml) was cooled to -78° C. under nitrogen and secondary butyrithium (1.3 M, 10 ml, 1.3 eq) was charged into the resulting solution for two hours. The solution was quenched with 1,4-dibromobutane (3.2 g) and allowed to stir at ambient temperature overnight. The nmixture was diluted with ethyl acetate, washed with water and brine, and concentrated to an oil. Following chromatography on a SiO2 column, 2.4 g of 2-(4-bromobutyl)anisole were obtained.

Provenance & Evidence