L-(+)-Cysteine → L-Phenylalanine

Participants

Reaction Steps

Yet another preferred group of antagonists has the following formula (including nontoxic salts thereof): (cyclo 30-33)Y-Asp-Leu-Thr-D-Phe-His-R14 -Leu-Arg-Glu-R18 -Leu-R20 -Nle-R22 -R23 -R24 -R25 -Gln-R27 -R28 -R29 -R30 -R31 -R32 -R33 -R34 -Arg-R36 -R37 -Nle-R39 -R40 -R41 -NH2 wherein Y is Ac, Acr or For; R14 is Leu or CML; R18 is Val, CML or Nle; R20 is Glu or D-Glu; R22 is Ala, Aib, D-Ala or Thr; R23 is Arg or Lys; R24 is Ala or Aib; R25 is Asp or Glu; R27 is Leu or CML; R28 is Ala or Aib; R29 is Gln or Glu; R30 is Glu or Cys; R31 is Ala or Aib; R32 is His, D-His, D-Arg, imBzlD-His, D-Nal, D-Glu, D-Ala, D-Pal, D-Trp, D-Dpr(Nic), D-Aph, D-Agl(Nic), D-Orn, D-Dbu, D-Dpr or D-Orn(Nic); R33 is Lys, Cys or Orn; R34 is Asn or Aib; R36 is Lys, CML or Leu; R37 is Leu or CML; R39 is Glu or Asp; R40 is Ile, CML, Aib or Glu; and R41 is Ile, Aib, CML or Ala; provided that when R30 is Cys, R33 is Cys; and when R30 is Glu, R33 is Orn or Lys; and provided further that D-2Nal or D-Leu or Phe may be substituted for D-Phe.

Provenance & Evidence