Ethylene Oxide → N-n-butyl-N-[1-(2-hydroxyethyl)-2,2,6,6-tetramethylpiperidin-4-yl]acetamide

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Reaction Steps

In general accordance with the procedure of Example 2Ag2, 27.2 g of crude product are obtained starting from 25.4 g (0.10 mol) of N-n-butyl-N-(2,2,6,6-tetramethyl-4-piperidinyl)acetamide [Example 2Ah1] and 17.6 g (0.40 mol) of ethylene oxide in 100 ml of water and 100 ml of ethanol. Chromatography over silica gel using the solvent system ethyl acetate/ethanol/triethylamine =30: 1:1 gives 17.2 (58%) of the desired N-n-butyl-N-[1-(2-hydroxyethyl)-2,2,6,6-tetramethylpiperidin-4-yl]acetamide in the form of a viscous oil which solidifies during storage; m.p. 72°-82° C.

Provenance & Evidence