Nitric Acid → 4-Tert-butyl-1-methoxy-2-nitrobenzene

HRID 1956031노트

반응식

HRID 1956031 반응식
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[N+:13]([O-])([OH:15])=[O:14]>C(Cl)CCl>[N+:13]([C:9]1[CH:10]=[C:5]([C:1]([CH3:4])([CH3:2])[CH3:3])[CH:6]=[CH:7][C:8]=1[O:11][CH3:12])([O-:15])=[O:14]

참가 물질

4

반응물 2

HCID 944Nitric AcidHCID 94750p-tert-Butylanisole

생성물 1

HCID 41784474-Tert-butyl-1-methoxy-2-nitrobenzene

시약·촉매·용매 1

HCID 111,2-Dichloroethane용매

실험 절차

Next is the mixing of one part 4-tert-butylanisole with between substantially 0-9 parts (by volume) organic solvent such as ethylene dichloride. Next is the cooling of the reaction mixture of 4-tert-butylamine and organic solvent to a temperature below 5° C. This is followed by the adding of 70% concentrated nitric acid while maintaining the temperature of the reaction mixture below 10° C. to produce 2-nitro-4-tertbutylanisole and a 4-nitroanisole byproduct. These are separated by means of vacuum distillation. Specifically, the 4-nitroanisole byproduct has a boiling point of 86° C. while the desired 2-nitro-4-tertbutylanisole has a boiling point of 102°-105° C. at a pressure of 1 mmHg.

후처리

  1. temperaturewhile maintaining the temperature of the reaction mixture below 10° C.

출처 및 근거

ORD 기록
ord-9c24900cd75a4cac9bfa8efd3215eb4c
출처 데이터셋
uspto-grants-1998_07
특허 번호
US05777168

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