Sodium Hydroxide → 5-Chloro-2,3,4-trifluorobenzoic acid

HRID 1956053Notes

Reaction equation

[Cl:1][C:2]1[C:3]([F:13])=[C:4]([F:12])[C:5]([F:11])=[C:6]([CH:10]=1)[C:7](F)=[O:8].[OH-:14].[Na+]>>[Cl:1][C:2]1[C:3]([F:13])=[C:4]([F:12])[C:5]([F:11])=[C:6]([CH:10]=1)[C:7]([OH:14])=[O:8]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 135650155-Chloro-2,3,4-trifluorobenzoyl fluoride

Product 1

HCID 101982165-Chloro-2,3,4-trifluorobenzoic acid

Procedure

When 5-chloro-2,3,4-trifluorobenzoyl fluoride is briefly treated with aqueous sodium hydroxide solution then, after acidification and drying, crystals of 5-chloro-2,3,4-trifluorobenzoic acid are obtained, melting point: 123°-4° C.

Workup

customafter acidification and drying

Sources & evidence

ORD record: ord-1c7f9feec397411a9b4c52f99e073ddd
Source dataset: uspto-grants-1998_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05777181

Reaction notes

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