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Ammonia → 3,5-Dichloro-2,4-difluorobenzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | 3,5-Dichloro-2,4-difluorobenzoyl fluoride | HCID 5463764 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 3,5-Dichloro-2,4-difluorobenzamide | HCID 13565027 | 90% |
反応手順
620 ml of concentrated aqueous ammonia solution and 600 ml of water are initially introduced, 458 g (2 moles) of 3,5-dichloro-2,4-difluorobenzoyl fluoride are added dropwise at 40°-50°, and then the mixture is stirred at 50° for 30 minutes. The precipitate is filtered off with suction, washed with water and dried. 408 g (90% of theory) of 3,5-dichloro-2,4-difluorobenzamide of melting point 163°-164° are obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05777181 |
| 出典データセット | uspto-grants-1998_07 |
| ORD ID | ord-fb7b1a51090a4444b0c61b84a030caf0 |
| 出典メモ | uspto-grants-1998_07 |