HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1956086Generated: November 2, 2026
2-[(Hept-6-yn-2-yl)oxy]oxane → 5-Benzyloxy-2-[4-(6-tetrahydropyranyloxy-1-heptynyl)phenyl]pyrimidine
https://huagongshe.com/reaction/1956086
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-[(Hept-6-yn-2-yl)oxy]oxane | HCID 13337174 | — |
| Reactant | 2-(4-Bromophenyl)-5-benzyloxypyrimidine | HCID 22358433 | — |
| Catalyst | Copper iodide | HCID 83717 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 5-Benzyloxy-2-[4-(6-tetrahydropyranyloxy-1-heptynyl)phenyl]pyrimidine | HCID 22358428 | — |
Reaction Steps
In a reactor equipped with a stirrer and a thermometer, 2-(4-bromophenyl)-5-benzyloxypyrimidine, 6-tetrahydropyranyloxy-1-heptyne, dichlorobis(triphenylphosphine)palladium, copper iodide, triphenylphosophine and triethylamine are charged and heated up to 90° C. to carry out a reaction for 8 hours. After extraction with toluene and washing with water, the mixture is evaporated under reduced pressure. A resulting residue is purified by silica gel column chromatography to obtain 5-benzyloxy-2-[4-(6-tetrahydropyranyloxy-1-heptynyl)phenyl]pyrimidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05779934 |
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| Source dataset | uspto-grants-1998_07 |
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| ORD ID | ord-044561e80c014bfbb56490ce05acc607 |
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| Source note | uspto-grants-1998_07 |
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