5-Benzyloxy-2-[4-(6-tetrahydropyranyloxy-1-heptynyl)phenyl]pyrimidine → 5-Hydroxy-2-[4-(6-tetrahydropyranyloxy1-heptyl)phenyl]pyrimidine

Participants

Reaction Steps

In a reactor equipped with a stirrer and a thermometer, 5-benzyloxy-2-[4-(6-tetrahydropyranyloxy-1-heptynyl)phenyl]pyrimidine, 5% Pd/C and THF are charged. After replacing an internal atmosphere of the reactor by hydrogen gas under atmospheric pressure, the mixture is reacted at room temperature for 10 hours in a hydrogen atmosphere under ordinary pressure. After filtrating the catalyst off, the reaction mixture is evaporated under reduced pressure. A resulting residue is purified by silica gel column chromatography to obtain 5-hydroxy-2-[4-(6-tetrahydropyranyloxy1-heptyl)phenyl]pyrimidine.

Provenance & Evidence