HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hexahydro-1,4-diazepine → 1-(2,3-Dihydro-6-methoxy-1H-inden-1-yl)hexahydro-1H-1,4-diazepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hexahydro-1,4-diazepine | HCID 68163 | — |
| Reactant | 6-Methoxy-1-Indanone | HCID 334036 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Catalyst | Titanium isopropoxide | HCID 11026 | — |
| Product | 1-(2,3-Dihydro-6-methoxy-1H-inden-1-yl)hexahydro-1H-1,4-diazepine | HCID 22375364 | 70.5% |
Reaction Steps
Homopiperazine (30.6 g, 0.306 mol), 6-methoxy-indan-1-one (4.95 g, 30.56 mmol), titanium(IV) isopropoxide (17.9 ml, 60 mmol) and sodium borohydride (2.7 g, 71 mmol) were reacted by Method A to give the product (5.3 g, 70.5%). The crude product was used without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05780470 |
| Source dataset | uspto-grants-1998_07 |
| ORD ID | ord-656b01bc73b24df498b317a5a8b9d510 |
| Source note | uspto-grants-1998_07 |