(1S)-(+)-Camphor-10-sulphonic acid → (-)-(6-methoxy-indan-1-yl)piperazine (1S)-10-camphorsulfonic acid salt

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Reaction Steps

A mixture of (6-methoxy-indan-1-yl)piperazine (2.3 g, 10 mmol) and (1S)-(+)-10-camphorsulfonic acid (2.3 g, 10 mmol) was recrystallized from ethanol-water until the crystal attained a constant melting point yielding (-)-(6-methoxy-indan-1-yl)piperazine (1S)-10-camphorsulfonic acid salt (22%, mp: 234.5°-234° C., [α]25D -36.3°). Calc'd for C14H20N2O2.C10 H10O4S: C, 62.04%; H, 7.81%; N, 6.03%. Found: C, 62.01%; H, 7.96; N, 5.97%.

Provenance & Evidence