Acetyl chloride → 1-Acetyl-4-(7-methoxy-tetralin-1-yl)piperazine

HRID 1956153Notes

Reaction equation

HRID 1956153 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH2:7][CH2:8][CH2:9][CH:10]2[N:13]2[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)=[CH:5][CH:4]=1.[C:19](Cl)(=[O:21])[CH3:20]>>[C:19]([N:16]1[CH2:15][CH2:14][N:13]([CH:10]2[C:11]3[C:6](=[CH:5][CH:4]=[C:3]([O:2][CH3:1])[CH:12]=3)[CH2:7][CH2:8][CH2:9]2)[CH2:18][CH2:17]1)(=[O:21])[CH3:20]

Participants

3

Reactant 2

HCID 6367Acetyl chlorideHCID 14601169(7-Methoxytetralin-1-yl)piperazine

Product 1

HCID 220379831-Acetyl-4-(7-methoxy-tetralin-1-yl)piperazine

Procedure

This compound was prepared from (7-methoxytetralin-1-yl)piperazine and acetyl chloride by the method described in Example 11 above (pale yellow oil, 58%). Calc'd for C17H24N2O2 : C, 69.93%; H, 8.43%; N, 9.60%. Found: C, 69.94%; H, 8.18%; N, 9.45%.

Sources & evidence

ORD record
ord-466e4964650249d6808eb3202ebc4e21
Source dataset
uspto-grants-1998_07
Patent number
US05780470

Reaction notes

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