1-(3-Phenoxyphenyl)piperazine → 1-[(5-Ethyl-2-methoxy-6-methylpyridin-3-yl)aminocarbonyl]-4-(3-phenoxyphenyl)piperazine

HRID 1956197Notes

Reaction equation

HRID 1956197 reaction equation
C1(O[C:8](=[O:21])[NH:9][C:10]2[C:11]([O:19][CH3:20])=[N:12][C:13]([CH3:18])=[C:14]([CH2:16][CH3:17])[CH:15]=2)C=CC=CC=1.[O:22]([C:29]1[CH:30]=[C:31]([N:35]2[CH2:40][CH2:39][NH:38][CH2:37][CH2:36]2)[CH:32]=[CH:33][CH:34]=1)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[CH2:16]([C:14]1[CH:15]=[C:10]([NH:9][C:8]([N:38]2[CH2:39][CH2:40][N:35]([C:31]3[CH:32]=[CH:33][CH:34]=[C:29]([O:22][C:23]4[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=4)[CH:30]=3)[CH2:36][CH2:37]2)=[O:21])[C:11]([O:19][CH3:20])=[N:12][C:13]=1[CH3:18])[CH3:17]

Participants

3

Reactant 2

HCID 184121551-(3-Phenoxyphenyl)piperazineHCID 19357010Phenyl N-(5-ethyl-2-methoxy-6-methylpyridin-3-yl)carbamate

Product 1

HCID 186631011-[(5-Ethyl-2-methoxy-6-methylpyridin-3-yl)aminocarbonyl]-4-(3-phenoxyphenyl)piperazineYield 72%

Procedure

Phenyl-N-(5-ethyl-2-methoxy-6-methylpyridin-3-yl)carbamate and 1-(3-phenoxyphenyl)piperazine were reacted by the same way with the example 1 to obtain the titled compound.

Sources & evidence

ORD record
ord-89a4406ae6dc41228ec56bc0b883a302
Source dataset
uspto-grants-1998_07
Patent number
US05780472

Reaction notes

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