Ethanol → HCID 18663120, compound

HRID 1956247Notes

Reaction equation

HRID 1956247 reaction equation
[CH2:1]([C:3]1[CH:4]=[C:5]([NH:12][C:13]([N:15]2[CH2:20][CH2:19][N:18](CC3C=CC=CC=3)[CH2:17][CH2:16]2)=[O:14])[C:6]([O:10][CH3:11])=[N:7][C:8]=1[CH3:9])[CH3:2].C(O)C>[Pd].C(O)(=O)C>[CH2:1]([C:3]1[CH:4]=[C:5]([NH:12][C:13]([N:15]2[CH2:16][CH2:17][NH:18][CH2:19][CH2:20]2)=[O:14])[C:6]([O:10][CH3:11])=[N:7][C:8]=1[CH3:9])[CH3:2]

Participants

5

Reactant 2

HCID 702EthanolHCID 18663117HCID 18663117, compound

Product 1

HCID 18663120HCID 18663120, compoundYield 93.5%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolvent

Procedure

After 1-[(5-ethyl-2-methoxy-6-methylpyridin-3-yl)aminocarbonyl]-4-benzyl piperazine (1.71 g, 4.61 mmol) was added the solution of 30 ml of ethanol and 10 ml of glacial acetic acid in the presence of 5% Pd/C, the reaction mixture were stirred under hydrogen gas(40 psi) for 4 hours and extracted with dichloromethane. The mixture was dried with anhydrous magnesium sulfate, filtrated, concentrated and chromatographed to obtain 1.2 g of white solid of the titled compound.

Workup

  1. extractionextracted with dichloromethane
  2. dry with materialThe mixture was dried with anhydrous magnesium sulfate
  3. filtrationfiltrated
  4. concentrationconcentrated
  5. customchromatographed

Sources & evidence

ORD record
ord-ffd0800071b140a98cb2839aabb8aeaa
Source dataset
uspto-grants-1998_07
Patent number
US05780472

Reaction notes

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