1-(3-Hydroxyphenyl)piperazine → 1-[(5,6-Dimethyl-2-methoxypyridin-3-yl)]-4-(3-hydroxyphenyl)piperazine

HRID 1956273Notes

Reaction equation

HRID 1956273 reaction equation
C1(O[C:8](=O)[NH:9][C:10]2[C:11]([O:18][CH3:19])=[N:12][C:13]([CH3:17])=[C:14]([CH3:16])[CH:15]=2)C=CC=CC=1.[OH:21][C:22]1[CH:23]=[C:24]([N:28]2[CH2:33]CN[CH2:30][CH2:29]2)[CH:25]=[CH:26][CH:27]=1>>[CH3:16][C:14]1[CH:15]=[C:10]([N:9]2[CH2:8][CH2:33][N:28]([C:24]3[CH:25]=[CH:26][CH:27]=[C:22]([OH:21])[CH:23]=3)[CH2:29][CH2:30]2)[C:11]([O:18][CH3:19])=[N:12][C:13]=1[CH3:17]

Participants

3

Reactant 2

HCID 27365971-(3-Hydroxyphenyl)piperazineHCID 11086894Phenyl N-(5,6-dimethyl-2-methoxypyridin-3-yl)carbamate

Product 1

HCID 186630491-[(5,6-Dimethyl-2-methoxypyridin-3-yl)]-4-(3-hydroxyphenyl)piperazineYield 78%

Procedure

Phenyl-N-(5,6-dimethyl-2-methoxypyridin-3-yl)carbamate and 1-(3-hydroxyphenyl)piperazine were reacted by the same way with the example 1 to obtain the titled compound.

Sources & evidence

ORD record
ord-91fcbd73d5f64cc888f650d9c7d93529
Source dataset
uspto-grants-1998_07
Patent number
US05780472

Reaction notes

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