1-(3-Chlorophenyl)piperazine → 1-[(5,6-Dimethyl-2-methoxypyridin-3-yl)aminothiocarbonyl]-4-(3-chlorophenyl) piperazine

HRID 1956284Notes

Reaction equation

HRID 1956284 reaction equation
C1(O[C:8](=[S:20])[NH:9][C:10]2[C:11]([O:18][CH3:19])=[N:12][C:13]([CH3:17])=[C:14]([CH3:16])[CH:15]=2)C=CC=CC=1.[Cl:21][C:22]1[CH:23]=[C:24]([N:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)[CH:25]=[CH:26][CH:27]=1>>[CH3:16][C:14]1[CH:15]=[C:10]([NH:9][C:8]([N:31]2[CH2:30][CH2:29][N:28]([C:24]3[CH:25]=[CH:26][CH:27]=[C:22]([Cl:21])[CH:23]=3)[CH2:33][CH2:32]2)=[S:20])[C:11]([O:18][CH3:19])=[N:12][C:13]=1[CH3:17]

Participants

3

Reactant 2

HCID 13551-(3-Chlorophenyl)piperazineHCID 53824458Phenyl N-(5,6-dimethyl-2-methoxypyridin-3-yl)thiocarbamate

Product 1

HCID 867529051-[(5,6-Dimethyl-2-methoxypyridin-3-yl)aminothiocarbonyl]-4-(3-chlorophenyl) piperazineYield 69%

Procedure

Phenyl-N-(5,6-dimethyl-2-methoxypyridin-3-yl)thiocarbamate and 1-(3-chlorophenyl)piperazine were reacted by the same way with the example 1 to obtain the titled compound.

Sources & evidence

ORD record
ord-29e6f3637d4c415a8d02776aeb74a908
Source dataset
uspto-grants-1998_07
Patent number
US05780472

Reaction notes

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