1-(2-Methoxyphenyl)piperazine → 1-[(5,6-Dimethyl-2-methoxypyridin-3-yl)aminocarbonyl]-4-(2-methoxyphenyl)piperazine

HRID 1956286Notes

Reaction equation

HRID 1956286 reaction equation
C1([O:7][C:8](=S)[NH:9][C:10]2[C:11]([O:18][CH3:19])=[N:12][C:13]([CH3:17])=[C:14]([CH3:16])[CH:15]=2)C=CC=CC=1.[CH3:21][O:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[N:29]1[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]1>>[CH3:16][C:14]1[CH:15]=[C:10]([NH:9][C:8]([N:32]2[CH2:31][CH2:30][N:29]([C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=3[O:22][CH3:21])[CH2:34][CH2:33]2)=[O:7])[C:11]([O:18][CH3:19])=[N:12][C:13]=1[CH3:17]

Participants

3

Reactant 2

HCID 13461-(2-Methoxyphenyl)piperazineHCID 53824458Phenyl N-(5,6-dimethyl-2-methoxypyridin-3-yl)thiocarbamate

Product 1

HCID 193571181-[(5,6-Dimethyl-2-methoxypyridin-3-yl)aminocarbonyl]-4-(2-methoxyphenyl)piperazineYield 70%

Procedure

Phenyl-N-(5,6-dimethyl-2-methoxypyridin-3-yl)thiocarbamate and 1-(2-methoxyphenyl)piperazine were reacted by the same way with the example 1 to obtain the titled compound.

Sources & evidence

ORD record
ord-47bdc9028d2c43d98868aec3145d6119
Source dataset
uspto-grants-1998_07
Patent number
US05780472

Reaction notes

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