反应详情

A mixture of 1.64 g of 10,11-dihydro-10-(4-iodobenzoyl)-5H-pyrrolo[2,1-c][1,4]benzodiazepine, 1.9 g of 2-tri-n-butylstannyl thiophene and 200 mg of tetrakis(triphenylphosphine)palladium(O) in 200 ml of toluene is refluxed under nitrogen for 16 hours. The reaction mixture is evaporated in vacuo to a residue which is purified by column chromatography on silica gel by elution with 5:1 hexane:ethyl acetate to give 1.2 g of the desired product as a solid. Mass spectrum: M+H:371.

1. temperatureis refluxed under nitrogen for 16 hours
2. customThe reaction mixture is evaporated in vacuo to a residue which
3. customis purified by column chromatography on silica gel by elution with 5:1 hexane