Ethanol → 2-Ethoxy-5-nitropyridine

Participants

Reaction Steps

2-Chloro-5-nitropyridine (30.0 g) was added to a solution of sodium metal (4.4 g) in absolute ethanol (250 ml) under a nitrogen atmosphere. The mixture was boiled under reflux for 4 hours, then cooled slightly and filtered. The filtrate was cooled in ice and filtered to give 2-ethoxy-5-nitropyridine, m.p. 85°-88° C.

Provenance & Evidence