2-Ethyl-5-nitropyridine → 6-Ethylpyridin-3-amine

HRID 1956410Notes

Reaction equation

HRID 1956410 reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([N+:9]([O-])=O)=[CH:5][N:4]=1)[CH3:2]>[Pd]>[NH2:9][C:6]1[CH:7]=[CH:8][C:3]([CH2:1][CH3:2])=[N:4][CH:5]=1

Participants

3

Reactant 1

HCID 45863822-Ethyl-5-nitropyridine

Product 1

HCID 138607296-Ethylpyridin-3-amine

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

2-Ethyl-5-nitropyridine (16.3 g) was dissolved in IMS (200 ml) and hydrogenated at ambient temperature at 1 atmosphere using 10% palladium charcoal (0.5 g) as the catalyst. The mixture was filtered to remove the catalyst and the filtrate evaporated to give 5-amino-2-ethylpyridine as an oil.

Workup

  1. filtrationThe mixture was filtered
  2. customto remove the catalyst
  3. customthe filtrate evaporated

Sources & evidence

ORD record
ord-f00d5da1b84846e3bc1b2c8879fc7088
Source dataset
uspto-grants-1998_07
Patent number
US05780482

Reaction notes

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