HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → Ethyl 4-chloro-6-methoxy-1,5-naphthyridine-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | HCID 178469604 | HCID 178469604 | — |
| Product | Ethyl 4-chloro-6-methoxy-1,5-naphthyridine-3-carboxylate | HCID 23209173 | — |
Reaction Steps
A mixture of ethyl 4-hydroxy-6-methoxy-1,5-naphthyridine-3-carboxylate (2.48 g) and phosphorus oxychloride (25 ml) was stirred and heated at 50°-55° C. for 30 minutes. The mixture was worked up as described in Example B1 to give ethyl 4-chloro-6-methoxy-1,5-naphthyridine-3-carboxylate, m.p. 98°-100° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05780482 |
| Source dataset | uspto-grants-1998_07 |
| ORD ID | ord-32298bd57f93488cae6c5c9e4df849fb |
| Source note | uspto-grants-1998_07 |