P-Anisidine → HCID 23209265, compound

Participants

Reaction Steps

A mixture of 4,7-dichloro-1,5-naphthyridine (0.65 g), 4-methoxyaniline (0.40 g) and IMS (25 ml) was boiled under reflux for 5 hours. The mixture was concentrated to approximately 5 ml and then ether added to induce precipitation. Ethyl acetate was added and the solid was collected by filtration to give 7-chloro-4-(4-methoxyanilino)-1,5-naphthyridine hydrochloride hydrate m.p. 230°-233° C.

Provenance & Evidence