P-Anisidine → HCID 131720765, compound

Participants

Reaction Steps

A mixture of ethyl 8-chloro-3-ethoxypyrido[2,3-b]-pyrazine-7-carboxylate (2.32 g) and 4-methoxyaniline (1.0 g) in ethanol (40 ml) was boiled under reflux for 1 hour. The mixture was allowed to cool and the solvent removed under reduced pressure. The residue was triturated with hot ethyl acetate and filtered to give a solid which was recrystallised from ethyl acetate to give a solid which was purified by chromatography on silica to give ethyl 3-ethoxy-8-(4-methoxyanilino)pyrido[2,3-b]pyrazine-7-carboxylate sesquihydrochloride hydrate, m.p. 143°-145° C.

Provenance & Evidence