HuagongsheHuagongshe Chemistry Print Report · For research reference only
P-Anisidine → Ethyl 4-(4-methoxyanilino)-6-ethoxy-7-methyl-1,8-naphthyridine-3-carboxylate hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | P-Anisidine | HCID 7732 | — |
| Reactant | Ethyl 4-chloro-6-ethoxy-7-methyl-1,8-naphthyridine-3-carboxylate | HCID 23198600 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ethyl 4-(4-methoxyanilino)-6-ethoxy-7-methyl-1,8-naphthyridine-3-carboxylate hydrochloride | HCID 19374282 | — |
Reaction Steps
A mixture of ethyl 4-chloro-6-ethoxy-7-methyl-1,8-naphthyridine-3-carboxylate (3.5 g) and 4-methoxyaniline (1.5 g) in ethanol (50 ml) was boiled under reflux for 1.5 hours. The mixture was concentrated to half the volume, cooled and ether added. The solid was collected by filtration to give ethyl 6-ethoxy-4-(4-methoxyanilino)-7-methyl-1,8-naphthyridine-3-carboxylate hydrochloride, m.p. 260°-262° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05780482 |
| Source dataset | uspto-grants-1998_07 |
| ORD ID | ord-d9bb40d2b2eb41268509d8b0d5bc31af |
| Source note | uspto-grants-1998_07 |