反应详情

A mixture of ethyl 4-chloro-6-ethoxy-7-methyl-1,8-naphthyridine-3-carboxylate (2.4 g), 5-amino-2-ethoxypyridine (1.15 g) and IMS (50 ml) was boiled under reflux for 1.5 hours. The mixture was cooled and filtered to give ethyl 6-ethoxy-4-(2-ethoxy-5-pyridylamino)-7-methyl-1,8-naphthyridine-3-carboxylate hydrochloride, m.p. 221°-223° C. Active (1/1) at 30 mg/kg.

1. temperatureunder reflux for 1.5 hours
2. temperatureThe mixture was cooled
3. filtrationfiltered