HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Ethoxy-2-pyridinamine → 3-Ethoxy-5-(6-ethoxy-2-pyridylamino)-2-methyl-1,8-naphthyridine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Ethoxy-2-pyridinamine | HCID 586710 | — |
| Reactant | 5-Chloro-3-ethoxy-2-methyl-1,8-naphthyridine | HCID 19374266 | — |
| Catalyst | Hydrochloric Acid | HCID 313 | — |
| Product | 3-Ethoxy-5-(6-ethoxy-2-pyridylamino)-2-methyl-1,8-naphthyridine hydrochloride | HCID 23209288 | — |
Reaction Steps
A mixture of 5-chloro-3-ethoxy-2-methyl-1,8 naphthyridine (0.98 g), 6-amino-2-ethoxypyridine (0.6 g), IMS (25 ml) and concentrated hydrochloric acid (2 drops) was boiled under reflux for 18 hours. The mixture was cooled and filtered to give 3-ethoxy-5-(6-ethoxy-2-pyridylamino)-2-methyl-1,8-naphthyridine hydrochloride, m.p. >250° C. Active (1/1) at 30 mg/kg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05780482 |
| Source dataset | uspto-grants-1998_07 |
| ORD ID | ord-9df1d179ccc64a039946b9f7b5eecca5 |
| Source note | uspto-grants-1998_07 |