HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(4-aminophenoxy)acetamide → Ethyl 4-[4-(carbamoylmethoxy)anilino]-6-ethoxy-7-methyl-1,8-naphthyridine-3-carboxylate hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(4-aminophenoxy)acetamide | HCID 3026006 | — |
| Reactant | Ethyl 4-chloro-6-ethoxy-7-methyl-1,8-naphthyridine-3-carboxylate | HCID 23198600 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ethyl 4-[4-(carbamoylmethoxy)anilino]-6-ethoxy-7-methyl-1,8-naphthyridine-3-carboxylate hydrochloride | HCID 23209291 | — |
Reaction Steps
A mixture of ethyl 4-chloro-6-ethoxy-7-methyl-1,8-naphthyridine-3-carboxylate (2.0 g), 4-aminophenoxy acetamide (1.13 g) and absolute ethanol (30 ml) was boiled under reflux for 1 hour and then cooled to ambient temperature. The mixture was filtered to give ethyl 4-[4-(carbamoylmethoxy)anilino]-6-ethoxy-7-methyl-1,8-naphthyridine-3-carboxylate hydrochloride, m.p. 215°-217° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05780482 |
| Source dataset | uspto-grants-1998_07 |
| ORD ID | ord-7f598e637b0145d69078de8a302c44bf |
| Source note | uspto-grants-1998_07 |