Ethyl 4-chloro-6-ethoxy-7-methyl-1,8-naphthyridine-3-carboxylate → HCID 178469689, compound

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Reaction Steps

A mixture of ethyl 4-chloro-6-ethoxy-7-methyl-1,8-naphthyridine-3-carboxylate (2.0 g), 5-aminopyrimidine-2,4-diol (0.86 g) and IMS (25 ml) was boiled under reflux for 3 hours. The mixture was concentrated to approximately 15 ml, then cooled at 0° C. The mixture was filtered to give ethyl 4-(2,4-dihydroxy-5-pyrimidinylamino)-6-ethoxy-7-methyl-1,8-naphthyridine-3-carboxylate hemihydrochloride dihydrate, m.p. 250° C. Active (1/1) at 30 mg/kg.

Provenance & Evidence