Pyridine, 5-amino-2,3'-oxydi- → HCID 23209183, compound

Participants

Reaction Steps

A mixture of 5-chloro-2-methyl-1,8-naphthyridine (1.8 g), 5-amino-2-(pyrid-3-yloxy)pyridine (1.87 g) and IMS (35 ml) was boiled under reflux for 5 hours. The mixture was cooled to ambient temperature and filtered to give a solid which was recrystallised from IMS to give 2-methyl-5-[2-(pyrid-3-yloxy)pyrid-5-ylamino]-1,8-naphthyridine hydrochloride 2.5 hydrate, m.p. 235°-237° C. Borderline active (1/1) at 30 mg/kg.

Provenance & Evidence