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Hydrochloric Acid → Ethyl 4-(6-ethoxy-3-ethoxycarbonyl-7-methyl-1,8-naphthyridin-4-ylamino)phenoxyacetate hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | (4-Nitrophenoxy)acetic acid | HCID 15720 | — |
| 反応物 | Ethyl 4-chloro-6-ethoxy-7-methyl-1,8-naphthyridine-3-carboxylate | HCID 23198600 | — |
| 反応物 | 2-(4-Aminophenoxy)acetic acid hydrochloride | HCID 66811488 | — |
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 生成物 | Ethyl 4-(6-ethoxy-3-ethoxycarbonyl-7-methyl-1,8-naphthyridin-4-ylamino)phenoxyacetate hydrochloride | HCID 23209201 | — |
反応手順
A mixture of ethyl 4-chloro-6-ethoxy-7-methyl-1,8-naphthyridine-3-carboxylate (3.1 g), 4-aminophenoxy-acetic acid hydrochloride (2.17 g) (prepared by reduction of 4-nitrophenoxyacetic acid using hydrogen and 10% palladium charcoal in a similar manner to Example C1 followed by treatment with 5M hydrochloric acid and then evaporation) and absolute ethanol (30 ml) was boiled under reflux for 4 hours. The mixture was cooled to ambient temperature and filtered to give ethyl 4-(6-ethoxy-3-ethoxycarbonyl-7-methyl-1,8-naphthyridin-4-ylamino)phenoxyacetate hydrochloride, m.p. 192°-194° C. Active (1/1) at 30 mg/kg.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05780482 |
| 出典データセット | uspto-grants-1998_07 |
| ORD ID | ord-37e46e3a8e6e4262905661911104d076 |
| 出典メモ | uspto-grants-1998_07 |