4-Pyridin-4-ylbutanal → HCID 178424871, compound

HRID 1956539Notes

Reaction equation

HRID 1956539 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([C:9]2[NH:10][C:11]3[C:16]([C:17]=2[CH2:18][CH2:19][NH2:20])=[CH:15][C:14]([C:21]([CH3:29])([C:23]2[NH:24][CH:25]=[C:26]([CH3:28])[N:27]=2)[CH3:22])=[CH:13][CH:12]=3)[CH:5]=[C:6]([CH3:8])[CH:7]=1.[N:30]1[CH:35]=[CH:34][C:33]([CH2:36][CH2:37][CH2:38][CH:39]=O)=[CH:32][CH:31]=1>>[CH3:1][C:2]1[CH:3]=[C:4]([C:9]2[NH:10][C:11]3[C:16]([C:17]=2[CH2:18][CH2:19][NH:20][CH2:39][CH2:38][CH2:37][CH2:36][C:33]2[CH:34]=[CH:35][N:30]=[CH:31][CH:32]=2)=[CH:15][C:14]([C:21]([CH3:29])([C:23]2[NH:24][CH:25]=[C:26]([CH3:28])[N:27]=2)[CH3:22])=[CH:13][CH:12]=3)[CH:5]=[C:6]([CH3:8])[CH:7]=1

Participants

3

Reactant 2

HCID 114464344-Pyridin-4-ylbutanalHCID 178424870HCID 178424870, compound

Product 1

HCID 178424871HCID 178424871, compound

Procedure

Prepared essentially as described in EXAMPLE 3.2D starting from 2-{2-(3,5-dimethylphenyl)-5-[1-methyl-1-(4-methyl-1H-imidazol-2-yl)ethyl]-1H-indol-3-yl}ethylamine (97 mg) and using 4-pyridin-4-yl butyraldehyde to give the title compound (73 mg). m/e=520 (M+1)

Workup

  1. customPrepared essentially

Sources & evidence

ORD record
ord-fbd8a4a8e86f4a9f9d4bff2d200417f7
Source dataset
uspto-grants-1998_07
Patent number
US05780437

Reaction notes

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