HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbon Dioxide → 5-Carboxy-2-ethylindole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbon Dioxide | HCID 280 | — |
| Reactant | 5-Chloro-2-methylindole | HCID 70636 | — |
| Reactant | 2-chloro-1H-indole | HCID 640840 | — |
| Reactant | 2-(2-Methyl-1-buten-4-yl)indole | HCID 18761628 | — |
| Product | 5-Carboxy-2-ethylindole | HCID 22708328 | — |
Reaction Steps
This synthesis could start with 5-chloro-2-methylindole, which could be alkylated with methyl indole (see 28a). The product chloroindole could then be converted to its Grignard species and exposed to carbon dioxide to finish the synthesis.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05780496 |
| Source dataset | uspto-grants-1998_07 |
| ORD ID | ord-abda413fe31542eba4950c0b6f1bf4c6 |
| Source note | uspto-grants-1998_07 |