HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuric Acid → HCID 22708335, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Sodium Nitrate | HCID 24268 | — |
| Reactant | 2-Ethyl-5-nitro-1H-indole | HCID 280310 | — |
| Reactant | 2-ethyl-1H-indole | HCID 3801618 | — |
| Reactant | Isopentylindol | HCID 11041488 | — |
| Product | HCID 22708335 | HCID 22708335 | — |
Reaction Steps
This synthesis could be achieved beginning with a standard nitration of 2-ethylindole using sodium nitrate and sulfuric acid similar to that cited in Yokoyama; Tanaka; Yamane; Kurita; Chem. Lett.; 7; 1991; 1125-1128. The resultant 5-nitro-2-ethylindole could be reduced to the desired amino compound using catalytic hydrogenation as in 28b).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05780496 |
| Source dataset | uspto-grants-1998_07 |
| ORD ID | ord-3aef9d8fa0394b50b1a99807dac5f6fe |
| Source note | uspto-grants-1998_07 |